Superior temporal gyrus volume in antipsychotic-naive people at risk of psychosis

T Takahashi; SJ Wood; AR Yung; M Walterfang; LJ Phillips; B Soulsby; Y Kawasaki; PD McGorry; M Suzuki; D Velakoulis; C Pantelis

Journal article

Superior temporal gyrus volume in antipsychotic-naive people at risk of psychosis

T Takahashi, SJ Wood, AR Yung, M Walterfang, LJ Phillips, B Soulsby, Y Kawasaki, PD McGorry, M Suzuki, D Velakoulis, C Pantelis

British Journal of Psychiatry | Published : 2010

DOI: 10.1192/bjp.bp.109.069732

Abstract

Background: Morphological abnormalities of the superior temporal gyrus have been consistently reported in schizophrenia, but the timing of their occurrence remains unclear. Aims: To determine whether individuals exhibit superior temporal gyral changes before the onset of psychosis. Method: We used magnetic resonance imaging to examine grey matter volumes of the superior temporal gyrus and its subregions (planum polare, Heschl's gyrus, planum temporale, and rostral and caudal regions) in 97 antipsychotic-naive individuals at ultra-high risk of psychosis, of whom 31 subsequently developed psychosis and 66 did not, and 42 controls. Results: Those at risk of psychosis had significantly smaller s..

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University of Melbourne Researchers

Stephen Wood Author

Mark Walterfang Author

Lisa Phillips Author

Patrick McGorry Author

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Grants

Awarded by Japan Society for the Promotion of Science

Funding Acknowledgements

7 he Study was supported by project grants from the National Health and Medical Research Council (NHMRC) (grants 145627, 145737, 970598, 981112, 970391), NHMRC programme giant 350241 and the Colonial Foundation. D.V. and S.J.W. were supported as research officers with funding from the NHMRC. I was supported by a Stanley Research Centre grant. P.D.M. was supported by an NARSAD Distinguished Investigator Award. S.J.W. is currently supported by a Clinical Career Development Award from the NHMRC (359223) and an NARSAD Young Investigator Award T.T. Was Supported to undertake this work by a grant-in-aid for scientific research (19591346) from the Japanese Society for the Promotion of Science, and a research grant (17-2, 18-6) for nervous and mental disorders from the Ministry of Health and welfare, Japan.Neuroimaging analysis was facilitated by the Neuropsychiatry Imaging Laboratory, managed by Ms Bridget Soulsby at the Melbourne Neuropsychiatry Centre, Australia, and supported by Neurosciences Victoria.